{"id":111,"date":"2026-10-16T01:47:31","date_gmt":"2026-10-15T16:47:31","guid":{"rendered":"https:\/\/fip.support\/blog\/?p=111"},"modified":"2026-10-16T02:00:44","modified_gmt":"2026-10-15T17:00:44","slug":"%e3%83%a2%e3%83%ab%e3%83%8c%e3%83%94%e3%83%a9%e3%83%93%e3%83%ab%e3%81%a7%e8%80%90%e6%80%a7%e3%81%8c%e5%87%ba%e3%82%8b%e3%81%a8%e3%80%81gs-441524%e3%82%82%e5%8a%b9%e3%81%8b%e3%81%aa%e3%81%8f%e3%81%aa","status":"publish","type":"post","link":"https:\/\/fip.support\/blog\/%e3%83%a2%e3%83%ab%e3%83%8c%e3%83%94%e3%83%a9%e3%83%93%e3%83%ab%e3%81%a7%e8%80%90%e6%80%a7%e3%81%8c%e5%87%ba%e3%82%8b%e3%81%a8%e3%80%81gs-441524%e3%82%82%e5%8a%b9%e3%81%8b%e3%81%aa%e3%81%8f%e3%81%aa\/","title":{"rendered":"\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3067\u8010\u6027\u304c\u51fa\u308b\u3068\u3001GS-441524\u3082\u52b9\u304b\u306a\u304f\u306a\u308b\u306e\u304b"},"content":{"rendered":"<div class=\"fip-doc\">\n<div class=\"fip-head\">\n<h1>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3067\u8010\u6027\u304c\u51fa\u308b\u3068\u3001GS-441524\u3082\u52b9\u304b\u306a\u304f\u306a\u308b\u306e\u304b<\/h1>\n<p class=\"fip-sub\">\u300c\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u6cbb\u7642\u306b\u5931\u6557\u3057\u305f\u732b\u306f\u3001GS-441524\u306b\u5207\u308a\u66ff\u3048\u3066\u3082\u30a6\u30a4\u30eb\u30b9\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u305f\u3081\u52b9\u304b\u306a\u3044\u300d\u3068\u3044\u3046\u8aac\u660e\u304c\u56fd\u5185\u3067\u6d41\u901a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e3b\u5f35\u3092\u88cf\u3065\u3051\u308b\u6587\u732e\u304c\u3042\u308b\u304b\u3092\u691c\u8a3c\u3057\u3001\u81e8\u5e8a\u3067\u4e0d\u5fdc\u306b\u898b\u3048\u308b\u75c7\u4f8b\u3092\u4f55\u304b\u3089\u7591\u3046\u3079\u304d\u304b\u3092\u6574\u7406\u3057\u307e\u3059\u3002<\/p>\n<\/p><\/div>\n<nav class=\"fip-toc\">\n<p class=\"toc-label\">\u76ee\u6b21<\/p>\n<ol>\n<li><a href=\"#claim\">\u6d41\u901a\u3057\u3066\u3044\u308b\u4e3b\u5f35<\/a><\/li>\n<li><a href=\"#evidence\">\u6587\u732e\u304c\u5b9f\u969b\u306b\u793a\u3057\u3066\u3044\u308b\u3053\u3068<\/a><\/li>\n<li><a href=\"#mechanism\">\u6a5f\u5e8f\u304b\u3089\u898b\u305f\u691c\u8a0e<\/a><\/li>\n<li><a href=\"#clinical\">\u81e8\u5e8a\u3067\u4e0d\u5fdc\u306b\u898b\u3048\u308b\u3068\u304d\u3001\u4f55\u3092\u7591\u3046\u304b<\/a><\/li>\n<li><a href=\"#hypothesis\">\u4f5c\u696d\u4eee\u8aac\uff1a\u524d\u6cbb\u7642\u304c\u30a6\u30a4\u30eb\u30b9\u306e\u591a\u69d8\u6027\u3092\u5e83\u3052\u308b\u53ef\u80fd\u6027<\/a><\/li>\n<li><a href=\"#verify\">\u691c\u8a3c\u306b\u5fc5\u8981\u306a\u30c7\u30fc\u30bf<\/a><\/li>\n<li><a href=\"#refs\">\u53c2\u8003\u6587\u732e<\/a><\/li>\n<\/ol>\n<\/nav>\n<div class=\"cal cal-stance\">\n    \u672c\u8a18\u4e8b\u306f\u3001\u56fd\u5185\u3067\u6d41\u901a\u3057\u3066\u3044\u308b\u4e00\u3064\u306e\u4e3b\u5f35\u306b\u3064\u3044\u3066\u30012026\u5e749\u6708\u6642\u70b9\u3067\u53c2\u7167\u3067\u304d\u308b\u67fb\u8aad\u6587\u732e\u3068\u7167\u3089\u3057\u5408\u308f\u305b\u305f\u691c\u8a3c\u3092\u884c\u3046\u3082\u306e\u3067\u3059\u3002\u7279\u5b9a\u306e\u7363\u533b\u5e2b\u30fb\u8ca9\u58f2\u8005\u30fb\u88fd\u54c1\u3092\u540d\u6307\u3057\u3059\u308b\u3053\u3068\u306f\u305b\u305a\u3001\u4e3b\u5f35\u305d\u306e\u3082\u306e\u306e\u6839\u62e0\u3092\u6271\u3044\u307e\u3059\u3002FIP\u30a6\u30a4\u30eb\u30b9\uff08FCoV\uff09\u3092\u76f4\u63a5\u306e\u5bfe\u8c61\u3068\u3057\u305f\u8010\u6027\u7814\u7a76\u306f\u304d\u308f\u3081\u3066\u9650\u3089\u308c\u308b\u305f\u3081\u3001\u672c\u8a18\u4e8b\u306e\u6a5f\u5e8f\u306b\u95a2\u3059\u308b\u8b70\u8ad6\u306e\u591a\u304f\u306f\u4ed6\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\u3001\u30de\u30a6\u30b9\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff09\u306e\u30c7\u30fc\u30bf\u306b\u4f9d\u62e0\u3057\u3066\u3044\u307e\u3059\u3002\u7a2e\u3092\u8d8a\u3048\u305f\u5916\u633f\u3067\u3042\u308b\u3053\u3068\u3092\u3001\u8aad\u8005\u306f\u5e38\u306b\u5ff5\u982d\u306b\u7f6e\u3044\u3066\u304f\u3060\u3055\u3044\u3002\n  <\/div>\n<h2 id=\"claim\">\u6d41\u901a\u3057\u3066\u3044\u308b\u4e3b\u5f35<\/h2>\n<p>  FIP\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u304c\u9078\u629e\u3055\u308c\u308b\u4f8b\u306f\u3001\u56fd\u5185\u3067\u306f\u73cd\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u30d2\u30c8\u7528\u306e\u6b63\u898f\u533b\u85ac\u54c1\u3068\u3057\u3066\u5165\u624b\u7d4c\u8def\u304c\u78ba\u7acb\u3057\u3066\u304a\u308a\u3001GS-441524\u88fd\u5264\u3068\u6bd4\u3079\u3066\u8cbb\u7528\u304c\u6291\u3048\u3089\u308c\u308b\u305f\u3081\u3067\u3059\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3067\u594f\u52b9\u3057\u306a\u304b\u3063\u305f\u75c7\u4f8b\u306b\u3064\u3044\u3066\u3001\u6b21\u306e\u3088\u3046\u306a\u8aac\u660e\u304c\u805e\u304b\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>  \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306f\u5909\u7570\u539f\u6027\u3092\u3082\u3064\u85ac\u5264\u3067\u3042\u308b\u305f\u3081\u3001\u6295\u4e0e\u306b\u3088\u3063\u3066FIP\u30a6\u30a4\u30eb\u30b9\u304c\u5909\u7570\u3057\u3066\u8010\u6027\u3092\u7372\u5f97\u3059\u308b\u3002\u5909\u7570\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u306b\u306fGS-441524\u3082\u52b9\u304b\u306a\u3044\u305f\u3081\u3001\u5207\u308a\u66ff\u3048\u3066\u3082\u7121\u99c4\u3067\u3042\u308b\u2014\u2014\u3068\u3044\u3046\u7b4b\u66f8\u304d\u3067\u3059\u3002<\/p>\n<p>  \u3053\u306e\u4e3b\u5f35\u304c\u6b63\u3057\u3051\u308c\u3070\u3001\u3069\u3061\u3089\u306e\u85ac\u5264\u3092\u5148\u306b\u4f7f\u3046\u304b\u306f\u6cbb\u7642\u6210\u7e3e\u3092\u5de6\u53f3\u3059\u308b\u6c7a\u5b9a\u7684\u306a\u5224\u65ad\u306b\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u8abf\u3079\u305f\u7bc4\u56f2\u3067\u306f\u3001<strong>\u3053\u306e\u4e3b\u5f35\u3092\u652f\u6301\u3059\u308b\u67fb\u8aad\u6e08\u307f\u306e\u75c7\u4f8b\u5831\u544a\u30fb\u81e8\u5e8a\u7814\u7a76\u30fb\u5b9f\u9a13\u30c7\u30fc\u30bf\u306f\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/strong><\/p>\n<div class=\"cal cal-key\">\n    <strong>\u3053\u306e\u8a18\u4e8b\u306e\u7d50\u8ad6<\/strong><br \/>\n    \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u8010\u6027\u304cGS-441524\u3078\u306e\u4ea4\u5dee\u8010\u6027\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3092\u793a\u3057\u305f\u6587\u732e\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u3002\u5b9f\u9a13\u7684\u306b\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3080\u3057\u308d\u9006\u3067\u3001\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\uff0fGS-441524\u3078\u306e\u8010\u6027\u3092\u4e0e\u3048\u308b\u7f6e\u63db\u306f\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u6d3b\u6027\u306b\u5f71\u97ff\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08Szemiel 2021\uff09\u3002\u81e8\u5e8a\u3067\u300c\u5207\u308a\u66ff\u3048\u3066\u3082\u52b9\u304b\u306a\u3044\u300d\u3088\u3046\u306b\u898b\u3048\u308b\u73fe\u8c61\u306f\u3001\u4ea4\u5dee\u8010\u6027\u4ee5\u5916\u306e\u8981\u56e0\u2014\u2014\u66dd\u9732\u4e0d\u8db3\u3001\u75c5\u671f\u306e\u9032\u5c55\u3001\u8a3a\u65ad\u306e\u4e0d\u78ba\u5b9f\u6027\u3001\u305d\u3057\u3066\u75c7\u4f8b\u9078\u629e\u306e\u504f\u308a\u2014\u2014\u3067\u3088\u308a\u7d20\u76f4\u306b\u8aac\u660e\u3067\u304d\u307e\u3059\u3002\n  <\/div>\n<h2 id=\"evidence\">\u6587\u732e\u304c\u5b9f\u969b\u306b\u793a\u3057\u3066\u3044\u308b\u3053\u3068<\/h2>\n<h3>\u85ac\u5264\u9593\u306e\u8010\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u5206\u96e2\u3057\u3066\u3044\u308b<\/h3>\n<p>  \u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u5b58\u5728\u4e0b\u3067SARS-CoV-2\u3092\u9023\u7d9a\u7d99\u4ee3\u3057\u3066\u8010\u6027\u3092\u9078\u629e\u3057\u305f\u7814\u7a76\u3067\u306f\u3001RdRp\uff08nsp12\uff09\u306bE802D\u7f6e\u63db\u304c\u751f\u3058\u307e\u3057\u305f\u3002\u3053\u306e\u7f6e\u63db\u306f\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u611f\u53d7\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u4e00\u65b9\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u80fd\u305d\u306e\u3082\u306e\u306b\u306f\u5f71\u97ff\u305b\u305a\u3001<strong>\u5225\u306e\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u30a2\u30ca\u30ed\u30b0\u3067\u3042\u308bEIDD-2801\uff08\uff1d\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\uff09\u306e\u6d3b\u6027\u3082\u5909\u3048\u307e\u305b\u3093\u3067\u3057\u305f<\/strong>\uff08Szemiel 2021\uff09\u3002\u540c\u3058\u9175\u7d20\u3092\u6a19\u7684\u306b\u3057\u3066\u3044\u3066\u3082\u3001\u52b9\u304b\u306a\u304f\u306a\u308b\u6761\u4ef6\u304c\u5225\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p>  \u3053\u308c\u306f\u300cGS\u8010\u6027\u2192\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306f\u52b9\u304f\u300d\u65b9\u5411\u306e\u8a3c\u62e0\u3067\u3042\u308a\u3001\u8cea\u554f\u3055\u308c\u3066\u3044\u308b\u300c\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u8010\u6027\u2192GS\u8010\u6027\u300d\u65b9\u5411\u3092\u76f4\u63a5\u691c\u8a3c\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305f\u3060\u3057\u3001\u4e21\u5264\u306e\u8010\u6027\u6c7a\u5b9a\u57fa\u304cRdRp\u4e0a\u3067\u72ec\u7acb\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3059\u70b9\u3067\u3001\u4ea4\u5dee\u8010\u6027\u3068\u3044\u3046\u524d\u63d0\u305d\u306e\u3082\u306e\u3092\u5f31\u3081\u307e\u3059\u3002<\/p>\n<h3>GS-441524\u3078\u306e\u8010\u6027\u7372\u5f97\u306f\u3001\u76f4\u63a5\u5727\u3092\u304b\u3051\u3066\u3082\u9045\u304f\u3001\u5f31\u3044<\/h3>\n<p>  \u3088\u308a\u91cd\u8981\u306a\u306e\u306f\u3001GS-441524\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u3069\u308c\u307b\u3069\u7372\u5f97\u3057\u306b\u304f\u3044\u304b\u3068\u3044\u3046\u5b9a\u91cf\u7684\u306a\u30c7\u30fc\u30bf\u3067\u3059\u3002\u7d30\u80de\u57f9\u990a\u7cfb\u3067\u85ac\u5264\u6fc3\u5ea6\u3092\u6bb5\u968e\u7684\u306b\u4e0a\u3052\u306a\u304c\u3089\u7d99\u4ee3\u3057\u305f\u5b9f\u9a13\u306e\u7d50\u679c\u306f\u3001\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n<div class=\"tw\">\n<table>\n<thead>\n<tr>\n<th>\u7d99\u4ee3\u5b9f\u9a13<\/th>\n<th>\u85ac\u5264\u5727<\/th>\n<th>\u5f97\u3089\u308c\u305f\u8010\u6027<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>MHV\u30fb23\u7d99\u4ee3<\/td>\n<td>GS-441524<\/td>\n<td>F476L\uff0bV553L\u306e2\u7f6e\u63db\u30675.6\u500d<\/td>\n<\/tr>\n<tr>\n<td>SARS-CoV-2\u30fb13\u7d99\u4ee3<\/td>\n<td>GS-441524<\/td>\n<td>V166A\u3092\u542b\u30804\u7f6e\u63db\u306e\u7d44\u5408\u305b\u306710\u500d<\/td>\n<\/tr>\n<tr>\n<td>SARS-CoV-2\u30fb17\u7d99\u4ee3<\/td>\n<td>\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb<\/td>\n<td>V166L\u5358\u72ec\u30672.3\u500d\uff08\u7d44\u63db\u3048\u4f53\u3067\u306f1.5\u500d\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>  \u85ac\u5264\u5727\u3092\u76f4\u63a5\u3001\u7d99\u7d9a\u7684\u306b\u3001\u6fc3\u5ea6\u3092\u4e0a\u3052\u306a\u304c\u3089\u304b\u3051\u7d9a\u3051\u3066\u3001\u3088\u3046\u3084\u304f13\u301c23\u7d99\u4ee3\u3067\u6570\u500d\u7a0b\u5ea6\u306e\u611f\u53d7\u6027\u4f4e\u4e0b\u304c\u5f97\u3089\u308c\u308b\u2014\u2014\u3053\u308c\u304c\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u304a\u3051\u308bGS-441524\uff0f\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u8010\u6027\u306e\u5b9f\u50cf\u3067\u3059\u3002\u8457\u8005\u3089\u306f\u3053\u308c\u3092\u300c\u8010\u6027\u306b\u5bfe\u3059\u308b\u9ad8\u3044\u907a\u4f1d\u7684\u969c\u58c1\u300d\u3068\u8868\u73fe\u3057\u3066\u3044\u307e\u3059\uff08Checkmahomed 2022\uff09\u3002<\/p>\n<p>  \u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u7f6e\u63db\u306f<em>\u9069\u5fdc\u5ea6\u30b3\u30b9\u30c8<\/em>\u3092\u4f34\u3044\u307e\u3059\u3002V166L\u3092\u7d44\u63db\u3048\u30a6\u30a4\u30eb\u30b9\u306b\u5c0e\u5165\u3059\u308b\u3068\u8907\u88fd\u304c\u4f4e\u4e0b\u3057\u3001\u5b9f\u969b\u306b\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u30923\u30b3\u30fc\u30b9\u76ee\u307e\u3067\u6295\u4e0e\u3055\u308c\u305f\u514d\u75ab\u4e0d\u5168\u60a3\u8005\u3067\u306f\u3001V166L\u3092\u3082\u3064\u96c6\u56e3\u304c\u6700\u7d42\u7684\u306b\u91ce\u751f\u578bnsp12\u3092\u3082\u3064\u30a6\u30a4\u30eb\u30b9\u306b\u7af6\u308a\u8ca0\u3051\u3066\u6d88\u3048\u3066\u3044\u307e\u3059\uff08Checkmahomed 2022\uff09\u3002E802D\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306b\u3001\u85ac\u5264\u975e\u5b58\u5728\u4e0b\u3067\u306e\u9069\u5fdc\u5ea6\u30b3\u30b9\u30c8\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08Gandhi 2022\uff09\u3002<\/p>\n<div class=\"cal cal-rule\">\n    \u85ac\u5264\u8010\u6027\u306f\u300c\u5909\u7570\u304c\u8d77\u304d\u305f\u304b\u3069\u3046\u304b\u300d\u3067\u306f\u6c7a\u307e\u308a\u307e\u305b\u3093\u3002\u7279\u5b9a\u306e\u6b8b\u57fa\u306b\u7279\u5b9a\u306e\u7f6e\u63db\u304c\u751f\u3058\u3001\u304b\u3064\u305d\u306e\u5909\u7570\u4f53\u304c\u96c6\u56e3\u306e\u4e2d\u3067\u512a\u52e2\u306b\u306a\u3063\u3066\u521d\u3081\u3066\u3001\u81e8\u5e8a\u7684\u306a\u8010\u6027\u3068\u3057\u3066\u73fe\u308c\u307e\u3059\u3002\u9069\u5fdc\u5ea6\u30b3\u30b9\u30c8\u3092\u4f34\u3046\u7f6e\u63db\u306f\u3001\u305d\u306e\u85ac\u5264\u304c\u306a\u3044\u74b0\u5883\u3067\u306f\u3080\u3057\u308d\u91ce\u751f\u578b\u306b\u62bc\u3057\u623b\u3055\u308c\u307e\u3059\u3002\n  <\/div>\n<h3>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u5909\u7570\u539f\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u4e8b\u5b9f\u95a2\u4fc2\u3092\u6b63\u78ba\u306b<\/h3>\n<p>  \u4e00\u65b9\u3067\u3001\u300c\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306b\u3088\u308b\u5909\u7570\u30a6\u30a4\u30eb\u30b9\u306f\u5168\u90e8\u6b7b\u306c\u300d\u3068\u3044\u3046\u5358\u7d14\u5316\u3082\u6b63\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002Sanderson\u3089\u306f\u4e16\u754c\u306eSARS-CoV-2\u914d\u5217\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u89e3\u6790\u3057\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u5c0e\u5165\u5f8c\u306e2022\u5e74\u4ee5\u964d\u306b\u306e\u307f\u73fe\u308c\u308b\u3001G\u2192A\u3068C\u2192T\u306b\u5f37\u304f\u504f\u3063\u305f\u9577\u3044\u7cfb\u7d71\u679d\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u5909\u7570\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u306f\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u6295\u4e0e\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u30a6\u30a4\u30eb\u30b9\u3068\u4e00\u81f4\u3057\u3001\u4e00\u90e8\u3067\u306f\u5909\u7570\u30a6\u30a4\u30eb\u30b9\u304c\u305d\u306e\u307e\u307e\u4ed6\u8005\u3078\u4f1d\u64ad\u3057\u3066\u3044\u307e\u3057\u305f\uff08Sanderson 2023\uff09\u3002<\/p>\n<p>  \u3064\u307e\u308a\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306f\u76f8\u5f53\u6570\u306e\u5909\u7570\u3092\u62b1\u3048\u305f\u307e\u307e\u751f\u5b58\u53ef\u80fd\u306a\u30a6\u30a4\u30eb\u30b9\u3092\u5b9f\u969b\u306b\u751f\u307f\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u554f\u984c\u306f\u3001\u305d\u3053\u304b\u3089\u300cGS-441524\u304c\u52b9\u304b\u306a\u3044\u300d\u307e\u3067\u306e\u8ddd\u96e2\u3067\u3059\u3002<\/p>\n<h2 id=\"mechanism\">\u6a5f\u5e8f\u304b\u3089\u898b\u305f\u691c\u8a0e<\/h2>\n<p>  \u4e21\u5264\u306f\u3069\u3061\u3089\u3082\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u30a2\u30ca\u30ed\u30b0\u3067RdRp\u306b\u4f5c\u7528\u3057\u307e\u3059\u304c\u3001\u4f5c\u7528\u306e\u69d8\u5f0f\u306f\u6b63\u53cd\u5bfe\u3067\u3059\u3002<\/p>\n<div class=\"tw\">\n<table>\n<thead>\n<tr>\n<th>\u9805\u76ee<\/th>\n<th>GS-441524<\/th>\n<th>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u4f5c\u7528<\/td>\n<td>RNA\u9396\u306e\u4f38\u9577\u3092\u6b62\u3081\u308b<br \/>\uff08chain termination\uff09<\/td>\n<td>\u5909\u7570\u3092\u5927\u91cf\u306b\u5c0e\u5165\u3059\u308b<br \/>\uff08error catastrophe\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u52b9\u304f\u6761\u4ef6<\/td>\n<td>\u85ac\u5264\u304cRdRp\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001<br \/>\u4f38\u9577\u304c\u505c\u6b62\u3059\u308b\u3053\u3068<\/td>\n<td>NHC\u304cC\/U\u306e\u4ee3\u308f\u308a\u306b<br \/>\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3053\u3068<\/td>\n<\/tr>\n<tr>\n<td>\u8010\u6027\u306e\u5f62<\/td>\n<td>\u6a19\u7684\u90e8\u4f4d\u306e\u7f6e\u63db\u3067\u56de\u907f\u3057\u3046\u308b<br \/>\uff08\u305f\u3060\u3057\u9069\u5fdc\u5ea6\u30b3\u30b9\u30c8\u3092\u4f34\u3046\uff09<\/td>\n<td>\u6a19\u7684\u90e8\u4f4d\u306e\u7f6e\u63db\u3067\u306f<br \/>\u539f\u7406\u7684\u306b\u56de\u907f\u3057\u306b\u304f\u3044<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>  \u3053\u3053\u304b\u3089\u3001\u5192\u982d\u306e\u4e3b\u5f35\u306b\u306f\u8ad6\u7406\u306e\u98db\u8e8d\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u5909\u7570\u539f\u306f\u591a\u69d8\u6027\u3092<em>\u751f\u6210<\/em>\u3057\u307e\u3059\u304c\u3001\u8010\u6027\u3092<em>\u9078\u629e<\/em>\u306f\u3057\u307e\u305b\u3093\u3002<\/p>\n<div class=\"fip-fig\">\n    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/fip.support\/blog\/wp-content\/uploads\/2026\/10\/fig-resistance-two-steps.png\"\n         alt=\"\u85ac\u5264\u8010\u6027\u304c\u81e8\u5e8a\u7684\u306b\u6210\u7acb\u3059\u308b\u306b\u306f\u3001\u5909\u7570\u306e\u751f\u6210\u3068\u9078\u629e\u306b\u3088\u308b\u6fc3\u7e2e\u3068\u3044\u30462\u3064\u306e\u6bb5\u968e\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u56f3\" width=\"1600\" height=\"1120\"><\/p>\n<p class=\"fip-cap\">\u56f31\uff1a\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u6295\u4e0e\u4e2d\u3001\u30a6\u30a4\u30eb\u30b9\u96c6\u56e3\u306b\u304b\u304b\u3063\u3066\u3044\u308b\u9078\u629e\u5727\u306f\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306b\u5bfe\u3059\u308b\u3082\u306e\u3060\u3051\u3067\u3059\u3002\u305d\u306e\u7cfb\u306bGS-441524\u306f\u5b58\u5728\u3057\u306a\u3044\u305f\u3081\u3001GS\u8010\u6027\u7f6e\u63db\u304c\u5076\u7136\u751f\u3058\u3066\u3082\u9078\u629e\u7684\u306a\u512a\u4f4d\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<\/p><\/div>\n<p>  \u52a0\u3048\u3066\u3001\u4eee\u306b\u4ea4\u5dee\u8010\u6027\u304c\u6210\u7acb\u3059\u308b\u3068\u3059\u308c\u3070\u3001\u305d\u306e\u30a6\u30a4\u30eb\u30b9\u306f3\u3064\u306e\u6761\u4ef6\u3092\u540c\u6642\u306b\u6e80\u305f\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u7531\u6765\u306e\u5909\u7570\u8377\u91cd\u3092\u62b1\u3048\u305f\u307e\u307e\u3001\u9069\u5fdc\u5ea6\u30b3\u30b9\u30c8\u3092\u4f34\u3046GS\u8010\u6027\u7f6e\u63db\u3092\uff08\u3057\u3070\u3057\u3070\u8907\u6570\u3001\u7d44\u307f\u5408\u308f\u305b\u3067\uff09\u7372\u5f97\u3057\u3001\u305d\u308c\u3067\u3044\u3066\u732b\u306e\u4f53\u5185\u3067\u5897\u6b96\u3092\u7d9a\u3051\u3066\u3044\u308b\u2014\u2014\u3068\u3044\u3046\u72b6\u614b\u3067\u3059\u3002\u524d\u7bc0\u306e\u7d99\u4ee3\u5b9f\u9a13\u304c\u793a\u3059\u3068\u304a\u308a\u3001\u76f4\u63a5\u306e\u85ac\u5264\u5727\u3092\u304b\u3051\u3066\u3059\u308913\u301c23\u7d99\u4ee3\u3092\u8981\u3059\u308b\u7d44\u5408\u305b\u304c\u3001\u85ac\u5264\u5727\u306e\u306a\u3044\u72b6\u6cc1\u3067\u5076\u7136\u305d\u308d\u3046\u78ba\u7387\u306f\u3001\u5358\u72ec\u6761\u4ef6\u306e\u78ba\u7387\u3088\u308a\u6841\u3067\u5c0f\u3055\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<div class=\"cal cal-warn\">\n    <strong>\u5e83\u307e\u308a\u3084\u3059\u3044\u8aa4\u89e3<\/strong><br \/>\n    \u300c\u30a6\u30a4\u30eb\u30b9\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u300d\u3053\u3068\u3068\u300c\u85ac\u5264\u8010\u6027\u3067\u3042\u308b\u300d\u3053\u3068\u306f\u540c\u3058\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306f\u5e38\u306b\u5909\u7570\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5927\u534a\u306f\u85ac\u5264\u611f\u53d7\u6027\u3068\u7121\u95a2\u4fc2\u304b\u3001\u30a6\u30a4\u30eb\u30b9\u81ea\u8eab\u306b\u4e0d\u5229\u306b\u50cd\u304d\u307e\u3059\u3002\u5909\u7570\u306e\u5b58\u5728\u306f\u8010\u6027\u306e\u8a3c\u660e\u306b\u306a\u308a\u307e\u305b\u3093\u3002\n  <\/div>\n<h2 id=\"clinical\">\u81e8\u5e8a\u3067\u4e0d\u5fdc\u306b\u898b\u3048\u308b\u3068\u304d\u3001\u4f55\u3092\u7591\u3046\u304b<\/h2>\n<p>  \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u5f8c\u306bGS-441524\u3078\u5207\u308a\u66ff\u3048\u3066\u53cd\u5fdc\u304c\u4e4f\u3057\u3044\u75c7\u4f8b\u304c\u5b9f\u5728\u3059\u308b\u3053\u3068\u306f\u3001\u304a\u305d\u3089\u304f\u78ba\u304b\u306a\u89b3\u5bdf\u3067\u3059\u3002\u305f\u3060\u3057\u305d\u306e\u8aac\u660e\u3068\u3057\u3066\u3001\u4ea4\u5dee\u8010\u6027\u3088\u308a\u5148\u306b\u691c\u8a0e\u3059\u3079\u304d\u3053\u3068\u304c\u8907\u6570\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3>\u691c\u8a0e\u306e\u9806\u5e8f<\/h3>\n<ul class=\"risk-stack\">\n<li>\n      <span class=\"rs-factor\">\u8a3a\u65ad\u306f\u78ba\u5b9a\u3057\u3066\u3044\u308b\u304b<\/span><br \/>\n      <span class=\"rs-why\">FIP\u306e\u78ba\u5b9a\u8a3a\u65ad\u306f\u3001\u7d44\u7e54\u30fb\u7d30\u80de\u6750\u6599\uff0bFCoV\u514d\u75ab\u67d3\u8272\u3001\u307e\u305f\u306f\u8caf\u7559\u6db2\u306e\u7d30\u80de\u8a3a\uff0b\u514d\u75ab\u67d3\u8272\uff0fRT-PCR\u306b\u9650\u3089\u308c\u308b\u3002\u8840\u6db2\u306eS\u907a\u4f1d\u5b50\u5909\u7570PCR\u306f\u78ba\u5b9a\u8a3a\u65ad\u306b\u306a\u3089\u306a\u3044<\/span>\n    <\/li>\n<li>\n      <span class=\"rs-factor\">\u85ac\u5264\u306f\u5c4a\u3044\u3066\u3044\u308b\u304b<\/span><br \/>\n      <span class=\"rs-why\">\u7d4c\u53e3GS-441524\u306e\u751f\u7269\u5b66\u7684\u5229\u7528\u7387\u306f\u500b\u4f53\u9593\u5909\u52d5\u304c\u5927\u304d\u304f\u3001\u6ce8\u5c04\u304b\u3089\u7d4c\u53e3\u3078\u306e\u63db\u7b97\u4fc2\u6570\u3082\u691c\u8a3c\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u8840\u4e2d\u6fc3\u5ea6\u3092\u6e2c\u3063\u3066\u3044\u306a\u3051\u308c\u3070\u3001\u8010\u6027\u3068\u4f4e\u66dd\u9732\u306f\u539f\u7406\u7684\u306b\u533a\u5225\u3067\u304d\u306a\u3044<\/span>\n    <\/li>\n<li>\n      <span class=\"rs-factor\">\u75c5\u671f\u306f\u9032\u5c55\u3057\u3066\u3044\u306a\u3044\u304b<\/span><br \/>\n      <span class=\"rs-why\">\u5207\u308a\u66ff\u3048\u6642\u70b9\u307e\u3067\u306b\u795e\u7d4c\u578b\u30fb\u773c\u578b\u3078\u306e\u9032\u5c55\u3084\u5168\u8eab\u72b6\u614b\u306e\u60aa\u5316\u304c\u8d77\u304d\u3066\u3044\u308c\u3070\u3001\u540c\u3058\u85ac\u5264\u3067\u3082\u6210\u7e3e\u306f\u5927\u304d\u304f\u5909\u308f\u308b<\/span>\n    <\/li>\n<li>\n      <span class=\"rs-factor\">\u5897\u91cf\u3067\u53cd\u5fdc\u3059\u308b\u304b<\/span><br \/>\n      <span class=\"rs-why\">\u907a\u4f1d\u7684\u8010\u6027\u306f\u7528\u91cf\u3067\u4e57\u308a\u8d8a\u3048\u306b\u304f\u3044\u304c\u3001\u66dd\u9732\u4e0d\u8db3\u306f\u7528\u91cf\u3067\u89e3\u6c7a\u3059\u308b\u3002\u5897\u91cf\u3078\u306e\u53cd\u5fdc\u306e\u6709\u7121\u306f\u3001\u4e21\u8005\u3092\u5206\u3051\u308b\u6700\u3082\u5b89\u4fa1\u306a\u6307\u6a19\u306b\u306a\u308b<\/span>\n    <\/li>\n<li>\n      <span class=\"rs-factor\">\u305d\u308c\u3067\u3082\u4e0d\u5fdc\u306a\u3089<\/span><br \/>\n      <span class=\"rs-why\">\u3053\u3053\u3067\u521d\u3081\u3066\u8010\u6027\u3092\u7591\u3046\u6bb5\u968e\u306b\u5165\u308b\u3002\u305f\u3060\u3057\u73fe\u6642\u70b9\u3067\u306f\u3001\u305d\u308c\u3092\u914d\u5217\u3067\u78ba\u8a8d\u3057\u305f\u5831\u544a\u306fFIP\u9818\u57df\u306b\u5b58\u5728\u3057\u306a\u3044<\/span>\n    <\/li>\n<\/ul>\n<h3>\u898b\u843d\u3068\u3055\u308c\u3084\u3059\u3044\u69cb\u9020\u7684\u306a\u504f\u308a<\/h3>\n<p>  \u3082\u3046\u3072\u3068\u3064\u3001\u81e8\u5e8a\u89b3\u5bdf\u3092\u8aad\u3080\u3046\u3048\u3067\u6c7a\u5b9a\u7684\u306b\u91cd\u8981\u306a\u70b9\u304c\u3042\u308a\u307e\u3059\u3002<strong>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3067\u594f\u52b9\u3057\u305f\u732b\u306f\u3001GS-441524\u306b\u5207\u308a\u66ff\u308f\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n<div class=\"fip-fig\">\n    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/fip.support\/blog\/wp-content\/uploads\/2026\/10\/fig-selection-bias.png\"\n         alt=\"\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u6cbb\u7642\u5f8c\u306bGS-441524\u3078\u5207\u308a\u66ff\u3048\u305f\u7fa4\u306b\u306f\u524d\u6cbb\u7642\u306e\u5931\u6557\u4f8b\u3060\u3051\u304c\u96c6\u307e\u308b\u305f\u3081\u3001\u6210\u7e3e\u304c\u4f4e\u304f\u898b\u3048\u308b\u69cb\u9020\u3092\u793a\u3059\u56f3\" width=\"1600\" height=\"1067\"><\/p>\n<p class=\"fip-cap\">\u56f32\uff1a\u3053\u306e\u504f\u308a\u306f\u3001\u89b3\u5bdf\u3055\u308c\u305f\u6210\u7e3e\u5dee\u304b\u3089\u4ea4\u5dee\u8010\u6027\u3092\u63a8\u8ad6\u3059\u308b\u3053\u3068\u3092\u96e3\u3057\u304f\u3057\u307e\u3059\u3002\u6bd4\u8f03\u304c\u6210\u308a\u7acb\u3064\u306e\u306f\u3001\u524d\u6cbb\u7642\u306e\u6709\u7121\u4ee5\u5916\u306e\u6761\u4ef6\uff08\u75c5\u578b\u30fb\u75c5\u671f\u30fb\u78ba\u5b9a\u8a3a\u65ad\u306e\u6709\u7121\u30fb\u8840\u4e2d\u6fc3\u5ea6\uff09\u3092\u63c3\u3048\u305f\u5834\u5408\u306b\u9650\u3089\u308c\u307e\u3059\u3002<\/p>\n<\/p><\/div>\n<p>  \u5b9f\u969b\u3001\u524d\u6cbb\u7642\u306e\u6709\u7121\u3067\u5c64\u5225\u3057\u306a\u3044\u6bd4\u8f03\u3067\u306f\u3001\u4e21\u5264\u306e\u6210\u7e3e\u306b\u5927\u304d\u306a\u5dee\u306f\u51fa\u3066\u3044\u307e\u305b\u3093\u3002\u56fd\u5185\u306e\u4e00\u65bd\u8a2d\u3067FIP\u732b118\u982d\u3092\u5bfe\u8c61\u306b\u3057\u305f\u5831\u544a\u3067\u306f\u3001\u6b7b\u4ea1\u306fGS-441524\u7fa412\/59\uff0820.3%\uff09\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u7fa48\/59\uff0813.6%\uff09\u3067\u7d71\u8a08\u5b66\u7684\u306a\u6709\u610f\u5dee\u306f\u306a\u304f\u3001\u6cbb\u7642\u3092\u5b8c\u9042\u3057\u305f\u75c7\u4f8b\u3067\u306fGS-441524\u7fa448\/48\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u7fa451\/52\u304c\u5bdb\u89e3\u306b\u81f3\u3063\u3066\u3044\u307e\u3059\uff08Sase 2024\uff09\u3002\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306b\u3088\u3063\u3066\u5e83\u7bc4\u306b\u8010\u6027\u304c\u7acb\u3061\u4e0a\u304c\u3063\u3066\u3044\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u3053\u3046\u3057\u305f\u6210\u7e3e\u306b\u306f\u306a\u308a\u306b\u304f\u3044\u306f\u305a\u3067\u3059\u3002<\/p>\n<h2 id=\"hypothesis\">\u4f5c\u696d\u4eee\u8aac\uff1a\u524d\u6cbb\u7642\u304c\u30a6\u30a4\u30eb\u30b9\u306e\u591a\u69d8\u6027\u3092\u5e83\u3052\u308b\u53ef\u80fd\u6027<\/h2>\n<div class=\"cal cal-warn\">\n    <strong>\u3053\u306e\u7bc0\u306e\u4f4d\u7f6e\u3065\u3051<\/strong><br \/>\n    \u4ee5\u4e0b\u306f\u691c\u8a3c\u3055\u308c\u3066\u3044\u306a\u3044\u4f5c\u696d\u4eee\u8aac\u3067\u3059\u3002\u67fb\u8aad\u6587\u732e\u306b\u3088\u308b\u88cf\u3065\u3051\u306f\u306a\u304f\u3001\u8a3a\u7642\u65b9\u91dd\u306e\u6839\u62e0\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u524d\u7bc0\u307e\u3067\u306e\u5185\u5bb9\u3068\u306f\u533a\u5225\u3057\u3066\u8aad\u3093\u3067\u304f\u3060\u3055\u3044\u3002\n  <\/div>\n<p>  \u3053\u3053\u307e\u3067\u306e\u691c\u8a0e\u306f\u3001\u5192\u982d\u306e\u4e3b\u5f35\u3092\u305d\u306e\u307e\u307e\u306e\u5f62\u3067\u306f\u652f\u6301\u3057\u307e\u305b\u3093\u3002\u305f\u3060\u3057\u3001\u73fe\u5834\u3067\u611f\u3058\u3089\u308c\u3066\u3044\u308b\u9055\u548c\u611f\u305d\u306e\u3082\u306e\u304c\u7684\u5916\u308c\u3060\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002\u4e3b\u5f35\u3092\u6a5f\u5e8f\u7684\u306b\u6210\u308a\u7acb\u3061\u3046\u308b\u5f62\u306b\u66f8\u304d\u76f4\u3059\u3068\u3001\u691c\u8a3c\u306b\u5024\u3059\u308b\u4eee\u8aac\u304c\u4e00\u3064\u6b8b\u308a\u307e\u3059\u3002<\/p>\n<h3>\u85ac\u306f\u300c\u8010\u6027\u3092\u4f5c\u308b\u300d\u306e\u3067\u306f\u306a\u304f\u300c\u304f\u3058\u306e\u679a\u6570\u3092\u5897\u3084\u3059\u300d\u306e\u304b\u3082\u3057\u308c\u306a\u3044<\/h3>\n<p>  \u8010\u6027\u304c\u81e8\u5e8a\u7684\u306b\u73fe\u308c\u308b\u306b\u306f2\u3064\u306e\u6bb5\u968e\u304c\u5fc5\u8981\u3067\u3057\u305f\uff08\u56f31\uff09\u3002\u2460\u8010\u6027\u3092\u3082\u3064\u30a6\u30a4\u30eb\u30b9\u304c\u96c6\u56e3\u306e\u4e2d\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u3001\u2461\u85ac\u3092\u6295\u4e0e\u3057\u305f\u3068\u304d\u306b\u305d\u308c\u304c\u751f\u304d\u6b8b\u3063\u3066\u5897\u3048\u308b\u3053\u3068\u3001\u306e2\u3064\u3067\u3059\u3002<\/p>\n<p>  \u91cd\u8981\u306a\u306e\u306f\u3001\u2461\u304c\u59cb\u307e\u308b\u306e\u306f\u85ac\u3092\u5165\u308c\u305f\u77ac\u9593\u3060\u3068\u3044\u3046\u70b9\u3067\u3059\u3002GS-441524\u3092\u6295\u4e0e\u3057\u305f\u6642\u70b9\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u96c6\u56e3\u306e\u4e2d\u306b\u305f\u307e\u305f\u307e\u8010\u6027\u3092\u3082\u3064\u500b\u4f53\u304c\u3044\u308c\u3070\u3001\u305d\u308c\u304c\u9078\u3073\u629c\u304b\u308c\u3066\u5897\u3048\u3066\u3044\u304d\u307e\u3059\u3002\u3044\u306a\u3051\u308c\u3070\u3001\u4f55\u3082\u8d77\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>  \u304f\u3058\u306b\u4f8b\u3048\u308b\u3068\u3001GS-441524\u306e\u6295\u4e0e\u306f\u300c\u62bd\u9078\u300d\u306b\u3042\u305f\u308a\u307e\u3059\u3002\u62bd\u9078\u3067\u5f53\u305f\u308b\u306b\u306f\u3001\u305d\u306e\u524d\u306b\u5f53\u305f\u308a\u304f\u3058\u3092\u6301\u3063\u3066\u3044\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>  \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306f\u62bd\u9078\u306e\u7d50\u679c\u3092\u64cd\u4f5c\u3057\u307e\u305b\u3093\u3002\u30a6\u30a4\u30eb\u30b9\u306bGS\u8010\u6027\u3092\u4e0e\u3048\u308b\u50cd\u304d\u306f\u306a\u3044\u304b\u3089\u3067\u3059\u3002\u3057\u304b\u3057\u3001<strong>\u914d\u3089\u308c\u308b\u304f\u3058\u306e\u679a\u6570\u3092\u5897\u3084\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u3002<\/strong>\u30e9\u30f3\u30c0\u30e0\u306a\u5909\u7570\u3092\u5927\u91cf\u306b\u5c0e\u5165\u3059\u308b\u85ac\u306a\u306e\u3067\u3001\u3075\u3060\u3093\u306f\u5b58\u5728\u3057\u306a\u3044\u5909\u7a2e\u304c\u4e00\u6642\u7684\u306b\u96c6\u56e3\u306e\u4e2d\u306b\u751f\u307e\u308c\u307e\u3059\u3002\u305d\u306e\u307b\u3068\u3093\u3069\u306f\u30cf\u30ba\u30ec\u2014\u2014\u30a6\u30a4\u30eb\u30b9\u306b\u3068\u3063\u3066\u4e0d\u5229\u304b\u3001\u81f4\u547d\u7684\u3067\u3059\u3002\u305d\u308c\u3067\u3082\u679a\u6570\u304c\u5897\u3048\u308c\u3070\u3001\u5f53\u305f\u308a\u304c\u7d1b\u308c\u8fbc\u3080\u78ba\u7387\u306f\u308f\u305a\u304b\u306b\u4e0a\u304c\u308a\u307e\u3059\u3002<\/p>\n<p>  \u3053\u308c\u304c\u4eee\u8aac\u306e\u4e2d\u8eab\u3067\u3059\u3002\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u304cGS\u8010\u6027\u3092<em>\u4f5c\u308a\u51fa\u3059<\/em>\u306e\u3067\u306f\u306a\u304f\u3001GS\u3092\u6295\u4e0e\u3059\u308b\u6642\u70b9\u3067\u30a6\u30a4\u30eb\u30b9\u96c6\u56e3\u304c\u3082\u3063\u3066\u3044\u308b\u591a\u69d8\u6027\u306e\u5e45\u3092<em>\u5e83\u3052\u3066\u3057\u307e\u3046<\/em>\u306e\u3067\u306f\u306a\u3044\u304b\u3002<em>\uff08\u96c6\u56e3\u907a\u4f1d\u5b66\u3067\u3044\u3046 standing variation \u306b\u3042\u305f\u308b\u8003\u3048\u65b9\u3067\u3059\uff09<\/em><\/p>\n<h3>\u554f\u984c\u306b\u306a\u308b\u306e\u306f\u300c\u4e2d\u9014\u534a\u7aef\u306b\u5c4a\u3044\u305f\u3068\u304d\u300d\u3060\u3051<\/h3>\n<p>  \u305f\u3060\u3057\u3001\u3053\u308c\u306f\u3069\u3093\u306a\u4f7f\u3044\u65b9\u3067\u3082\u8d77\u304d\u308b\u8a71\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6210\u7acb\u3059\u308b\u6761\u4ef6\u306f\u304b\u306a\u308a\u9650\u3089\u308c\u307e\u3059\u3002<\/p>\n<div class=\"fip-fig\">\n    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/fip.support\/blog\/wp-content\/uploads\/2026\/10\/fig-partial-dose.png\"\n         alt=\"\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u5c4a\u304d\u65b9\u306b\u3088\u3063\u3066\u30a6\u30a4\u30eb\u30b9\u96c6\u56e3\u306e\u591a\u69d8\u6027\u304c\u3069\u3046\u5909\u308f\u308b\u304b\u3092\u3001\u5341\u5206\u91cf\u30fb\u6295\u4e0e\u306a\u3057\u30fb\u4e2d\u9014\u534a\u7aef\u306a\u91cf\u306e3\u3064\u306e\u5834\u5408\u3067\u6bd4\u8f03\u3057\u305f\u56f3\" width=\"1600\" height=\"1053\"><\/p>\n<p class=\"fip-cap\">\u56f33\uff1a\u5341\u5206\u306b\u52b9\u304b\u305b\u308b\u304b\u3001\u307e\u3063\u305f\u304f\u4f7f\u308f\u306a\u3044\u304b\u3067\u3042\u308c\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u96c6\u56e3\u306e\u591a\u69d8\u6027\u306f\u5e83\u304c\u308a\u307e\u305b\u3093\u30023\u756a\u76ee\u306e\u72b6\u614b\u3060\u3051\u304c\u300c\u6b7b\u306a\u305b\u306a\u3044\u307e\u307e\u5909\u7570\u3055\u305b\u7d9a\u3051\u308b\u300d\u6761\u4ef6\u3092\u6e80\u305f\u3057\u307e\u3059\u3002<\/p>\n<\/p><\/div>\n<p>  FIP\u3067\u3053\u306e\u6761\u4ef6\u304c\u6210\u7acb\u3057\u3084\u3059\u3044\u306e\u306f\u3001\u85ac\u304c\u5c4a\u304d\u306b\u304f\u3044\u5834\u6240\u3067\u3059\u3002\u4e2d\u67a2\u795e\u7d4c\u3001\u8089\u82bd\u816b\u306e\u5185\u90e8\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u4e2d\u2014\u2014\u3053\u3046\u3057\u305f\u5834\u6240\u3067\u306f\u8840\u4e2d\u3068\u540c\u3058\u6fc3\u5ea6\u3092\u78ba\u4fdd\u3057\u306b\u304f\u304f\u3001\u6295\u4e0e\u91cf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308c\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u3092\u6b62\u3081\u304d\u308c\u306a\u3044\u7a0b\u5ea6\u306e\u6fc3\u5ea6\u306e\u307e\u307e\u6570\u9031\u9593\u304c\u904e\u304e\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>  \u30d2\u30c8\u306eSARS-CoV-2\u3067\u3082\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306b\u3088\u308b\u5909\u7570\u306e\u75d5\u8de1\u304c\u5f37\u304f\u6b8b\u3063\u3066\u3044\u305f\u306e\u306f\u3001\u611f\u67d3\u3092\u6700\u5f8c\u307e\u3067\u6392\u9664\u3067\u304d\u306a\u304b\u3063\u305f\u60a3\u8005\u304b\u3089\u3067\u3057\u305f\uff08Sanderson 2023\uff09\u3002\u300c\u85ac\u3092\u4f7f\u3063\u3066\u3044\u308b\u306e\u306b\u30a6\u30a4\u30eb\u30b9\u304c\u6b8b\u308a\u7d9a\u3051\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u3053\u306e\u72b6\u614b\u306f\u3001\u96e3\u6cbb\u6027\u306eFIP\u3068\u69cb\u9020\u304c\u3088\u304f\u4f3c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>\u3069\u3061\u3089\u304c\u6b63\u3057\u3044\u304b\u3067\u3001\u7d50\u8ad6\u306f\u6b63\u53cd\u5bfe\u306b\u306a\u308b<\/h3>\n<p>  \u5143\u306e\u4e3b\u5f35\u3068\u3053\u306e\u4eee\u8aac\u306f\u3001\u4f3c\u3066\u3044\u308b\u3088\u3046\u3067\u81e8\u5e8a\u7684\u306a\u7d50\u8ad6\u304c\u9006\u3092\u5411\u304d\u307e\u3059\u3002<\/p>\n<p>  \u4ea4\u5dee\u8010\u6027\u304c\u85ac\u7406\u5b66\u7684\u306a\u5fc5\u7136\u306a\u3089\u3001\u554f\u984c\u306f\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3092<strong>\u4f7f\u3046\u3053\u3068<\/strong>\u305d\u306e\u3082\u306e\u3067\u3059\u3002\u4f7f\u3048\u3070\u5fc5\u305a\u8d77\u304d\u308b\u306e\u3060\u304b\u3089\u3001\u907f\u3051\u308b\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u4e00\u65b9\u3053\u306e\u4eee\u8aac\u304c\u6b63\u3057\u3051\u308c\u3070\u3001\u554f\u984c\u306f\u4f7f\u3046\u3053\u3068\u3067\u306f\u306a\u304f<strong>\u4e2d\u9014\u534a\u7aef\u306b\u4f7f\u3046\u3053\u3068<\/strong>\u3067\u3059\u3002\u91cf\u304c\u8db3\u308a\u306a\u3044\u3001\u671f\u9593\u304c\u77ed\u3044\u3001\u5438\u53ce\u304c\u60aa\u3044\u72b6\u614b\u306e\u307e\u307e\u6f2b\u7136\u3068\u7d9a\u3051\u308b\u2014\u2014\u3053\u308c\u304c\u6700\u3082\u5371\u306a\u3044\u4f7f\u3044\u65b9\u3067\u3042\u308a\u3001\u9006\u306b\u5341\u5206\u91cf\u3092\u78ba\u5b9f\u306b\u5c4a\u3051\u3066\u77ed\u671f\u3067\u6c7a\u7740\u3092\u3064\u3051\u308b\u306a\u3089\u3001\u30ea\u30b9\u30af\u306f\u3080\u3057\u308d\u4e0b\u304c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<div class=\"cal cal-key\">\n    \u5143\u306e\u4e3b\u5f35\u304c\u6b63\u3057\u3051\u308c\u3070\u300c\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3092\u4f7f\u3046\u306a\u300d\u304c\u7d50\u8ad6\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u4eee\u8aac\u304c\u6b63\u3057\u3051\u308c\u3070\u300c\u4f7f\u3046\u306a\u3089\u4e2d\u9014\u534a\u7aef\u306b\u3059\u308b\u306a\u300d\u304c\u7d50\u8ad6\u306b\u306a\u308a\u307e\u3059\u3002\u3069\u3061\u3089\u306a\u306e\u304b\u306f\u3001\u6b21\u7bc0\u306e\u30c7\u30fc\u30bf\u3092\u53d6\u308c\u3070\u533a\u5225\u3067\u304d\u307e\u3059\u3002\n  <\/div>\n<h2 id=\"verify\">\u691c\u8a3c\u306b\u5fc5\u8981\u306a\u30c7\u30fc\u30bf<\/h2>\n<p>  \u3053\u306e\u4e8c\u3064\u306e\u8aac\u660e\u2014\u2014\u4ea4\u5dee\u8010\u6027\u3068\u3001\u66dd\u9732\u4e0d\u8db3\u30fb\u75c7\u4f8b\u9078\u629e\u2014\u2014\u306f\u3001\u8a18\u9332\u306e\u53d6\u308a\u65b9\u6b21\u7b2c\u3067\u5207\u308a\u5206\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n<div class=\"tw\">\n<table>\n<thead>\n<tr>\n<th>\u89b3\u5bdf\u9805\u76ee<\/th>\n<th>\u4ea4\u5dee\u8010\u6027\u8aac<\/th>\n<th>\u66dd\u9732\u30fb\u9078\u629e\u8aac<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>GS\u5897\u91cf<\/td>\n<td>\u53cd\u5fdc\u3057\u306a\u3044<\/td>\n<td>\u53cd\u5fdc\u3059\u308b<\/td>\n<\/tr>\n<tr>\n<td>\u524d\u6cbb\u7642\u671f\u9593<\/td>\n<td>\u9577\u3044\u307b\u3069\u4e0d\u5fdc<\/td>\n<td>\u76f8\u95a2\u3057\u306a\u3044<\/td>\n<\/tr>\n<tr>\n<td>\u5207\u66ff\u6642\u75c5\u578b<\/td>\n<td>\u75c5\u578b\u3068\u7121\u95a2\u4fc2\u306b\u4e0d\u5fdc<\/td>\n<td>\u795e\u7d4c\u578b\u30fb\u773c\u578b\u306b\u504f\u308b<\/td>\n<\/tr>\n<tr>\n<td>GS\u8840\u4e2d\u6fc3\u5ea6<\/td>\n<td>\u6cbb\u7642\u57df\u306a\u306e\u306b\u4e0d\u5fdc<\/td>\n<td>\u6cbb\u7642\u57df\u306b\u9054\u3057\u3066\u3044\u306a\u3044<\/td>\n<\/tr>\n<tr>\n<td>RdRp\u914d\u5217<\/td>\n<td>G\u2192A\uff0fC\u2192U\u504f\u308a\u3068\u7f6e\u63db<\/td>\n<td>\u7279\u7b46\u3059\u3079\u304d\u5909\u5316\u306a\u3057<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>  \u81e8\u5e8a\u306e\u5834\u3067\u307e\u305a\u53d6\u308a\u7d44\u3081\u308b\u306e\u306f\u4e0a\u304b\u30894\u884c\u3067\u3059\u3002\u3068\u304f\u306b\u5897\u91cf\u3078\u306e\u53cd\u5fdc\u306f\u3001\u8ffd\u52a0\u30b3\u30b9\u30c8\u304c\u307b\u3068\u3093\u3069\u304b\u304b\u3089\u306a\u3044\u3046\u3048\u306b\u8b58\u5225\u529b\u304c\u9ad8\u304f\u3001\u5897\u91cf\u3067\u53cd\u5fdc\u3059\u308b\u75c7\u4f8b\u304c\u4e00\u5b9a\u6570\u3042\u308c\u3070\u3001\u305d\u308c\u3060\u3051\u3067\u4ea4\u5dee\u8010\u6027\u8aac\u306f\u307b\u307c\u5426\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>  \u6700\u7d42\u884c\u306b\u3064\u3044\u3066\u306f\u3001\u3072\u3068\u3064\u91cd\u8981\u306a\u6280\u8853\u7684\u88dc\u8db3\u304c\u3042\u308a\u307e\u3059\u3002<strong>\u3069\u306e\u7f6e\u63db\u304c\u8010\u6027\u3092\u4e0e\u3048\u308b\u304b\u3092\u77e5\u3089\u306a\u304f\u3066\u3082\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u66dd\u9732\u306e\u75d5\u8de1\u306f\u691c\u51fa\u3067\u304d\u307e\u3059\u3002<\/strong>Sanderson\u3089\u306e\u624b\u6cd5\u306f\u7279\u5b9a\u306e\u8010\u6027\u5909\u7570\u3067\u306f\u306a\u304f\u3001G\u2192A\u3068C\u2192U\u3078\u306e\u504f\u308a\u3068\u3044\u3046\u5909\u7570\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u305d\u306e\u3082\u306e\u3092\u898b\u308b\u3082\u306e\u3067\u3059\uff08Sanderson 2023\uff09\u3002\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u4e0d\u5fdc\u4f8b\u306e\u8caf\u7559\u6db2\u304b\u3089FCoV\u306eRdRp\u9818\u57df\u3092\u8aad\u307f\u3001\u3053\u306e\u504f\u308a\u304c\u8a8d\u3081\u3089\u308c\u306a\u3051\u308c\u3070\u3001\u4eee\u8aac\u306f\u305d\u306e\u6642\u70b9\u3067\u5426\u5b9a\u3055\u308c\u307e\u3059\u3002\u8a8d\u3081\u3089\u308c\u308c\u3070\u3001FIP\u9818\u57df\u3067\u306f\u524d\u4f8b\u306e\u306a\u3044\u6240\u898b\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>  \u8a18\u9332\u3057\u3066\u304a\u304f\u3068\u5f8c\u304b\u3089\u89e3\u6790\u53ef\u80fd\u306b\u306a\u308b\u9805\u76ee\u306f\u3001\u524d\u6cbb\u7642\u306e\u85ac\u5264\u30fb\u7528\u91cf\u30fb\u5b9f\u6295\u4e0e\u65e5\u6570\u3001\u5207\u308a\u66ff\u3048\u6642\u70b9\u306e\u75c5\u578b\u3068\u4e3b\u8981\u691c\u67fb\u5024\u3001\u5207\u308a\u66ff\u3048\u5f8c\u306eGS-441524\u306e\u6295\u4e0e\u7d4c\u8def\u30fb\u7528\u91cf\u30fb\u8840\u4e2d\u6fc3\u5ea6\u3001\u5897\u91cf\u306e\u6709\u7121\u3068\u305d\u306e\u5f8c\u306e\u53cd\u5fdc\u3001\u305d\u3057\u3066\u53ef\u80fd\u3067\u3042\u308c\u3070\u5207\u308a\u66ff\u3048\u524d\u5f8c\u306e\u8caf\u7559\u6db2\u307e\u305f\u306f\u7d44\u7e54\u691c\u4f53\u306e\u4fdd\u5b58\u3067\u3059\u3002<\/p>\n<div class=\"cal cal-rule\">\n    <strong>\u8a18\u9332\u3059\u308b\u75c7\u4f8b\u306e\u9078\u3073\u65b9<\/strong><br \/>\n    \u6c7a\u5b9a\u7684\u306a\u306e\u306f\u3001\u5370\u8c61\u306b\u6b8b\u3063\u305f\u75c7\u4f8b\u3060\u3051\u3092\u9078\u3070\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u5207\u308a\u66ff\u3048\u3066\u52b9\u304b\u306a\u304b\u3063\u305f\u732b\u3060\u3051\u3092\u8a18\u9332\u3059\u308c\u3070\u3001\u56f32\u3067\u8ff0\u3079\u305f\u504f\u308a\u3092\u81ea\u5206\u306e\u624b\u3067\u518d\u73fe\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u610f\u5473\u306e\u3042\u308b\u30c7\u30fc\u30bf\u306b\u306a\u308b\u306e\u306f\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u304b\u3089\u5207\u308a\u66ff\u3048\u305f\u75c7\u4f8b\u3092\u9023\u7d9a\u3057\u3066\u2014\u2014\u594f\u52b9\u4f8b\u3082\u4e0d\u5fdc\u4f8b\u3082\u533a\u5225\u305b\u305a\u2014\u2014\u8a18\u9332\u3057\u305f\u5834\u5408\u306b\u9650\u3089\u308c\u307e\u3059\u3002\u4ef6\u6570\u304c\u5c11\u306a\u304f\u3066\u3082\u3001\u9023\u7d9a\u8a18\u9332\u3067\u3042\u308c\u3070\u89e3\u91c8\u3067\u304d\u307e\u3059\u3002\u9078\u3093\u3067\u96c6\u3081\u305f\u75c7\u4f8b\u306f\u3001\u4f55\u4ef6\u3042\u3063\u3066\u3082\u89e3\u91c8\u3067\u304d\u307e\u305b\u3093\u3002\n  <\/div>\n<h2 id=\"refs\">\u53c2\u8003\u6587\u732e<\/h2>\n<ol class=\"fip-refs\">\n<li>Szemiel AM, Merits A, Orton RJ, et al. In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2. <em>PLoS Pathog<\/em>. 2021;17(9):e1009929. doi:10.1371\/journal.ppat.1009929<\/li>\n<li>Checkmahomed L, Carbonneau J, Du Pont V, et al. In vitro selection of remdesivir-resistant SARS-CoV-2 demonstrates high barrier to resistance. <em>Antimicrob Agents Chemother<\/em>. 2022;66(7):e00198-22. doi:10.1128\/aac.00198-22<\/li>\n<li>Agostini ML, Andres EL, Sims AC, et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. <em>mBio<\/em>. 2018;9(2):e00221-18. doi:10.1128\/mBio.00221-18<\/li>\n<li>Gandhi S, Klein J, Robertson AJ, et al. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report. <em>Nat Commun<\/em>. 2022;13(1):1547. doi:10.1038\/s41467-022-29104-y<\/li>\n<li>Sanderson T, Hisner R, Donovan-Banfield I, et al. A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes. <em>Nature<\/em>. 2023;623(7987):594\u2013600. doi:10.1038\/s41586-023-06649-6<\/li>\n<li>Sase O, Iwami T, Sasaki T, Sano T. GS-441524 and molnupiravir are similarly effective for the treatment of cats with feline infectious peritonitis. <em>Front Vet Sci<\/em>. 2024;11:1422408. doi:10.3389\/fvets.2024.1422408<\/li>\n<li>Pedersen NC, Perron M, Bannasch M, et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. <em>J Feline Med Surg<\/em>. 2019;21(4):271\u2013281. doi:10.1177\/1098612X19825701<\/li>\n<\/ol>\n<div class=\"cal cal-disclaimer\">\n    \u672c\u8a18\u4e8b\u306f\u4e00\u822c\u7684\u306a\u60c5\u5831\u63d0\u4f9b\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u3001\u500b\u3005\u306e\u732b\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u65b9\u91dd\u3092\u793a\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5b9f\u969b\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306f\u7363\u533b\u5e2b\u306e\u8a3a\u5bdf\u3068\u6307\u5c0e\u306e\u3082\u3068\u3067\u884c\u3063\u3066\u304f\u3060\u3055\u3044\u3002\n  <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3067\u8010\u6027\u304c\u51fa\u308b\u3068\u3001GS-441524\u3082\u52b9\u304b\u306a\u304f\u306a\u308b\u306e\u304b \u300c\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u6cbb\u7642\u306b\u5931\u6557\u3057\u305f\u732b\u306f\u3001GS-441524\u306b\u5207\u308a\u66ff\u3048\u3066\u3082\u30a6\u30a4\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[4],"tags":[],"class_list":["post-111","post","type-post","status-publish","format-standard","hentry","category-4"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/posts\/111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/comments?post=111"}],"version-history":[{"count":2,"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/posts\/111\/revisions"}],"predecessor-version":[{"id":113,"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/posts\/111\/revisions\/113"}],"wp:attachment":[{"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/media?parent=111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/categories?post=111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fip.support\/blog\/wp-json\/wp\/v2\/tags?post=111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}